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目的探讨戊乙奎醚治疗有机磷农药中毒的临床效果。方法将有机磷农药中毒患者随机分为盐酸戊乙奎醚组和阿托品组,采用临床治疗推荐剂量进行治疗,并对治疗效果进行比较。结果戊乙奎醚组昏迷至清醒时间,治疗时间明显缩短,用药量及次数少,用药后心率无明显增快,治疗率高和阿托品组比较,差异有统计学意义(P<0.01)。结论戊乙奎醚是治疗急性有机磷中毒的理想抗胆碱药应值得推广和应用。
Objective To investigate the clinical effect of penehyclidine on organophosphorus pesticide poisoning. Methods Patients with organophosphate pesticide poisoning were randomly divided into penehyclidine hydrochloride group and atropine group. The patients were treated with the recommended dose of clinical treatment and the therapeutic effects were compared. Results Penehyclidine group coma to awake time, the treatment time was significantly shorter, the amount and frequency of medication, no significant increase in heart rate after treatment, the treatment rate was higher and atropine group, the difference was statistically significant (P <0.01). Conclusion Penehyclidine is an ideal anticholinergic agent for the treatment of acute organophosphate poisoning and should be popularized and applied.