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目的探讨干扰素治疗慢性乙型肝炎对患者T淋巴细胞CD28表达的影响。方法符合纳入标准的慢性乙型肝炎患者112例,给予干扰素α-2b抗病毒治疗,疗程为12个月,治疗前后测定并比较患者淋巴细胞CD28表达情况。结果治疗后,患者CD4+CD28+T细胞由(0.43±0.1)×109/L增加至(0.56±0.2)×109/L,CD8+CD28+T细胞由(0.19±0.2)×109/L增加至(0.31±0.1)×109/L,CD28的表达均明显高于治疗前,比较差异有统计学意义(P<0.05)。高病毒载量组与低病毒载量组患者治疗后T淋巴细胞CD28表达差异无统计学意义(P>0.05)。结论干扰素α-2b可以有效增加慢性乙型肝炎患者T淋巴细胞CD28的表达,其抗病毒作用可能与有效激活CD4+CD28+和CD8+CD28+T细胞有关。
Objective To investigate the effect of interferon on CD28 expression in T lymphocytes of patients with chronic hepatitis B. Methods A total of 112 patients with chronic hepatitis B were enrolled in the study. Interferon alfa-2b antiviral therapy was given for 12 months. Before and after treatment, CD28 expression in lymphocytes was measured and compared. Results After treatment, CD4 + CD28 + T cells increased from (0.43 ± 0.1) × 109 / L to (0.56 ± 0.2) × 109 / L and CD8 + CD28 + T cells increased from (0.19 ± 0.2) × 109 / L (0.31 ± 0.1) × 109 / L, the expression of CD28 was significantly higher than before treatment, the difference was statistically significant (P <0.05). There was no significant difference in the expression of CD28 on T lymphocytes between high viral load group and low virus load group (P> 0.05). Conclusions Interferon α-2b can effectively increase the expression of CD28 on T lymphocytes in patients with chronic hepatitis B, and its antiviral effect may be related to the effective activation of CD4 + CD28 + and CD8 + CD28 + T cells.