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目的:探讨维拉帕米(Verapamil)膀胱灌注联合甲氰咪胍治疗间质性膀胱炎的有效性和安全性。方法:2006年4月~2015年3月对52例女性间质性膀胱炎患者采用Verapamil膀胱灌注联合甲氰咪胍进行治疗,病程12~48个月,平均30个月,其中51例为慢性膀胱炎,1例为间质性膀胱炎。具体方法是Verapamil 40mg+0.9%生理盐水40ml行膀胱灌注,每天1次,每次保留30min;再静脉滴注甲氰咪胍0.4g,每天1次,7天为一疗程。治疗前后进行O’Leary-sant问卷评分。结果:治疗1周后,患者下腹部胀痛不适、尿频尿急症状明显改善,膀胱区疼痛改善率为88.46%(46/52),尿频尿急改善率为85.71%(42/49),夜尿次数改善率为79.54%(35/44)。随访3个月后,膀胱区疼痛改善率为82.69%(43/52),尿频尿急改善率为77.55%(38/49),夜尿次数改善率为72.73%(32/44)。治疗和随访中未见明确不良反应。治疗前后O’Leary-sant问卷评分差异有统计学意义(P<0.05)。结论:Verapamil膀胱灌注联合甲氰咪胍能有效缓解间质性膀胱炎的临床症状,改善其生活质量,是一种安全有效的治疗方法。
Objective: To investigate the efficacy and safety of verapamil combined with cromimegilide in the treatment of interstitial cystitis. Methods: From April 2006 to March 2015, 52 patients with interstitial cystitis were treated with Verapamil intravesical instillation and cimetidine for a duration of 12 months to 48 months (average 30 months), of which 51 were chronic Cystitis, 1 case of interstitial cystitis. The specific method is Verapamil 40mg + 0.9% saline 40ml bladder perfusion, once a day, each time for 30min; and then intravenous cimetidine 0.4g, 1 day, 7 days for a course of treatment. O’Leary-sant questionnaire score before and after treatment. Results: After 1 week of treatment, the patient suffered from lower abdominal discomfort and urinary frequency and urgency. The rate of pain relief in bladder area was 88.46% (46/52), urinary frequency and urgency improvement rate was 85.71% (42/49), night Urine frequency improvement rate was 79.54% (35/44). Three months after follow-up, the improvement rate of pain in bladder area was 82.69% (43/52), urinary urgency improvement rate was 77.55% (38/49) and nocturnal urination improvement rate was 72.73% (32/44). No clear adverse reactions were observed during treatment and follow-up. The score of O’Leary-sant questionnaire before and after treatment had statistical significance (P <0.05). Conclusion: Verapamil intravesical instillation combined with cimetidine can effectively relieve the clinical symptoms of interstitial cystitis and improve the quality of life. It is a safe and effective treatment.