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目的了解大丽菊花提取物对人体有无致突变性和致畸作用。方法对大丽菊花提取物进行了3项致突变试验和致畸试验的研究。结果该受试物Aems试验、微核试验、中国仓鼠肺细胞(CHL)染色体畸变试验均为阴性。致畸试验表明,7200mg/kg剂量组可导致胎仔身长、体重的下降及囟门的增大,但对胎仔的外观、内脏及骨骼畸形率均无影响。结论大丽菊花提取物对人体无致突变性和致畸作用。
Objective To understand whether the extract of daisy chrysanthemum has mutagenic and teratogenic effects on the human body. Methods Three mutagenic and teratogenic tests were carried out on the dahlia flower extract. Results The subjects Aems test, micronucleus test, Chinese hamster lung cells (CHL) chromosome aberration test were negative. Teratogenicity test showed that 7200mg / kg dose group can lead to fetal body length, weight loss and fontanelle increase, but the appearance of fetal, visceral and skeletal deformity rate had no effect. Conclusion Dahlia flower extract has no mutagenic and teratogenic effects on human body.