龋病的发生发展过程中,致龋微生物生物膜(biofilm)形成是龋病发生的首要因素。变形链球菌(Streptococcus mutans)等在口腔生物膜内进行产酸代谢活动是产生龋病的直接原因。因此,控制S.mutans生物膜的形成可以减少龋病的发生、发展。本文就影响变形链球菌生物膜形成的因素研究进展做一综述。 During the development of dental caries, the formation of cariogenic biofilm is the primary factor of dental caries. Streptococcus mutans and other oral biofilm acid-producing metabolic activity is the direct cause of caries. Therefore, the control of S.mutans biofilm formation can reduce the occurrence and development of dental caries. This review summarizes the research progress on the factors affecting the formation of Streptococcus mutans biofilm.