This study aims to produce 229Th using an innovative nuclear reactor concept, i.e., accelerator-driven system (ADS) reactor. Herein, we investigated the feasi-bility of producing 229Th from neutron transmutation of 226Ra to expand the availability of 225Ac and 213Bi in a simple model of ADS reactor. ADS reactor comprises two zones, i.e., an inner zone with a fast neutron spectrum and outer zone with thermal neutron spectrum, which is a subcritical core coupled with an exteal neutron source. Transmutation behavior, activity, and mass ratio of the obtained isotopes were investigated using the Monte-Carlo tool. In addition with offering the capability, flexibility, and safety of radioactive waste transmutation, the proposed ADS model provides high 229Th yield and requires less time than a critical reactor with the same neutronflux and irradiated quantity of 226Ra.