论文部分内容阅读
原发Ⅰ型艾滋病病毒(HIV-1)感染(PHI)包括急性期感染(AHI)和早期感染(EHI)。AHI通常与急性的“反转录病毒综合征”有关,包括一系列非特异的症状和实验室检测异常。AHI和EHI的分界点在于HIV抗体的阳转,而PHI和其后的慢性感染阶段的临界点在于体内何时达到HIV-1的调定点。早期诊断有赖于检测HIV-1RNA和P24抗原。大约50%经性传染HIV发生在急性期阶段,对急性期/早期感染者尽早诊断并给予抗病毒治疗,能明显减少HIV的传播。一些研究显示,早期抗病毒治疗能够使病毒得以长期抑制,并能保持甚至增加HIV-1特异性T细胞免疫应答,但早期治疗和治疗中断的临床益处还没有足够数据支持。
Primary HIV-1 infection (PHI) includes acute phase infection (AHI) and early infection (EHI). AHI is usually associated with acute “retroviral syndromes” and includes a number of non-specific symptoms and laboratory abnormalities. The boundary between AHI and EHI lies in the positive rotation of HIV antibodies, whereas the critical point in PHI and subsequent chronic infection phases is when the in vivo target of HIV-1 is reached. Early diagnosis depends on the detection of HIV-1 RNA and P24 antigens. Approximately 50% of sexually transmitted HIV occurs in the acute phase and early diagnosis and administration of antiviral therapy for acute / early infections can significantly reduce the spread of HIV. Some studies have shown that early antiviral treatment can long-term virus suppression and maintain or even increase HIV-1-specific T cell immune response, but the clinical benefits of early treatment and treatment discontinuation have not enough data to support.