本文综述甲氧氯普胺的不良反应,并重点介绍锥体外系严重反应的3种临床类型。急性肌张力障碍性反应发生于用药早期,停药后能自行消失;帕金森综合征及迟发性运动障碍多见于长期治疗的病人,恢复需要相当时间,后者往往迁延,甚至不能逆转。作者强调防止不良反应的重要性并提出初步建议。 This article reviews the adverse reactions of metoclopramide and highlights three clinical types of extrapyramidal reactions. Acute dystonia occurs in the early medication, withdrawal can disappear on their own; Parkinson’s disease and tardive dyskinesia more common in patients with long-term treatment, recovery takes time, the latter often delay, or even not reversed. The authors emphasize the importance of preventing adverse reactions and make preliminary recommendations.