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目的：了解血小板源性生长因子（ＰＤＧＦ）和碱性成纤维细胞生长因子（ｂＦＧＦ）在视网膜增殖膜细胞的表达及其与增殖性玻璃体视网膜病变（ＰＶＲ）的关系。方法：免疫组化法研究ＰＤＧＦ和ｂＦＧＦ在２０例视网膜前膜和１例视网膜下膜（视网膜脱离术后继发）细胞中的表达情况。结果：①１５／２１（７１．４％）例标本对抗ＰＤＧＦ抗体呈阳性反应，１４／２１（６６．７％）例对抗ｂＦＧＦ呈阳性反应；②Ｅａｌｅｓ病和增殖性糖尿病视网膜病引起的血管增殖性前膜（≥６１个细胞／视野，１０００×）较ＰＶＲ引起的非血管增殖性前膜（３１～６０个细胞／视野）内细胞密度高，黄斑前膜（≤３０个细胞／视野）最低。结论：ＰＤＧＦ和ｂＦＧＦ在ＰＶＲ发展过程中起重要作用；ＰＶＲ膜上增殖细胞可产生ｂＦＧＦ，它是导致严重ＰＶＲ时玻璃体内ｂＦＧＦ含量异常升高的主要原因。
OBJECTIVE: To investigate the expression of platelet derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) in retinal proliferating cell and its relationship with proliferative vitreoretinopathy (PVR). Methods: The expression of PDGF and bFGF in 20 cases of pre-retinal membrane and 1 case of subretinal membrane (secondary to retinal detachment) were studied by immunohistochemistry. Results: ①15 of 21 (71.4%) specimens showed positive reaction to anti-PDGF antibody and 14 of 21 (66.7%) showed positive response to bFGF. ②Eales disease and proliferative diabetic retinopathy- Membranes (≥61 cells / field, 1000 ×) had higher cell densities than PVR-induced non-vascular proliferative membranes (31-60 cells / field) with the pre-macular membrane (≤30 cells / field) the lowest. CONCLUSION: PDGF and bFGF play an important role in the development of PVR. Proliferating cells in PVR membrane can produce bFGF, which is the main reason for the abnormal increase of bFGF in vitreous in severe PVR.