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根据Farr氏的硫酸铵技术,我们采用~(125)I-DNA方法测定了正常人和各种病人的抗双链DNA抗体的结合率。结合活性>20％为阳性。阳性率在SLE病人为63.7％,非SLE结缔组织病为18％,其它疾病12％,正常人仅为7％。有肾脏受累的活动期病人中结合率均>40％。与ANA试验比较放射免疫抗DNA抗体试验敏感性较差,但比较特异。 随着疾病的活动抗DNA抗体升高和补体下降之间有一定关系。因此抗DNA抗体试验不仅可作为一个诊断方法,而且对于SLE有肾脏受累的病人的治疗前后可以作疾病活动性的监护试验。
According to Farr’s ammonium sulfate technique, we measured the binding rate of anti-dsDNA antibodies in normal and various patients using the ~ (125) I-DNA method. Binding activity> 20% positive. The positive rate was 63.7% in patients with SLE, non-SLE connective tissue disease was 18%, other diseases 12%, normal only 7%. In patients with active kidney involvement, the combined rate was> 40%. Compared with the ANA test radioimmunoassay anti-DNA antibody test less sensitive, but more specific. There is a relationship between increased anti-DNA antibody and decreased complement as the disease progresses. Therefore, anti-DNA antibody test can not only be used as a diagnostic method, but also for SLE patients with kidney involvement before and after treatment for disease activity monitoring test.