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大量蛋白尿是肾病综合征(NS)早期的重要特点,蛋白尿本身也可能作为一个独立的致病因素参与肾小管间质损害的病理过程,加速肾脏疾病的进展。评价肾小管间质损伤的程度对NS的预后和治疗有指导作用,为此我们回顾了195例成人原发性NS患者的临床和肾脏病理资料,探讨与肾小管间质损害相关的危险因素。
Massive proteinuria is an early feature of nephrotic syndrome (NS). Proteinuria may also participate in the pathological process of tubulointerstitial injury as an independent pathogenic factor to accelerate the progression of renal disease. To assess the extent of tubulointerstitial injury has a guiding role in the prognosis and treatment of NS. To this end, we reviewed the clinical and renal pathological data of 195 adult patients with primary NS and explored the risk factors associated with tubulointerstitial damage.