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目的:探讨胰岛素样生长因子Ⅰ(IGF- Ⅰ)在新生儿细菌感染时的意义。方法:生后3 d内入院的儿科新生儿病人,入院后予测C 反应蛋白(CRP)、免疫球蛋白M(IgM)、血常规、胸片、血培养以及IGF -Ⅰ。按新生儿感染诊断标准诊断感染组30例,对照非感染组20例。结果:感染组与非感染组比较WBC、CRP、IgM、IGF -Ⅰ有显著差异(P<0.05)。结论: IGF 1 的降低可反映细菌性感染的存在。
Objective: To investigate the significance of insulin-like growth factor Ⅰ (IGF-Ⅰ) in neonatal bacterial infection. Methods: Pediatric neonates admitted to hospital within 3 days after birth were enrolled in the study. CRP, IgM, blood routine, chest X-ray, blood culture and IGF-Ⅰ were determined after admission. According to the diagnostic criteria of neonatal infection, 30 cases were diagnosed as infection group and 20 cases as control non-infected group. Results: There were significant differences in WBC, CRP, IgM and IGF-Ⅰ between infected group and non-infected group (P <0.05). Conclusion: The decrease of IGF 1 may reflect the existence of bacterial infection.