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本组5例难治性卵巢癌,4例为第二次手术后盆腔内复发,1例为Ⅲ期癌只行活检。经用多疗程顺铂为基础的全身化疗无效后采用双髂内动脉保留导管灌药。顺铂30～40mg/日5次,联用阿霉素20mg/日5次,或联用环磷酰胺200mg/日5次。2例获显效,2例有效,1例无效。动脉内给药量大于静脉用药(20mg/日5次),然毒副反应不重于静脉用药。本文还对插管的解剖学、药代动力学的依据及是否并用栓塞进行了讨论。
The group of 5 cases of refractory ovarian cancer, 4 cases of pelvic recurrence after the second surgery, 1 case of stage Ⅲ cancer only biopsy. After multiple courses of cisplatin-based systemic chemotherapy with double internal iliac artery retention catheter irrigation. Cisplatin 30 ~ 40mg / day 5 times, with doxorubicin 20mg / day 5 times, or combined with cyclophosphamide 200mg / day 5 times. Two cases were markedly effective, two were effective, and one was ineffective. Intra-arterial administration is greater than the intravenous medication (20mg / day 5 times), but no more than side effects of intravenous drug toxicity. This article also discusses the anatomy and pharmacokinetics of intubation and whether embolism is used together.