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硝苯吡啶(nifedipine, NFP)是目前应用广泛的钙拮抗剂,始用于治疗心绞痛、高血压、充血性心力衰竭(心衰)等。现已发展为治疗支气管哮喘、雷若氏现象、泌尿道梗阻、偏头痛、腹痛、消化性溃疡、保护肝细胞、抑制子宫收缩等。但本品也存在一些副作用,有的症状、体征还较严重。本文综合有关文献对NFP的副作用叙述如下。一、诱发和加重心衰 Robson报道1例因卧位性心绞痛患者,1年前发生前壁心内膜下梗塞,投有氨酰心安,消心痛和NFP2周后发生下壁心内膜下梗塞,有呼吸困难和肺郁血,心胸比率为16/30,给予利尿剂治疗后气促渐消,5日后患者明显心衰,肺与外周水肿。需利尿治疗,停用NFP后4个月心衰未发展,再用NFP20 mg,每日3次重新治疗,3天后由于心绞痛加剧和呼吸困难而停药,随后症状改善。Coloucci和O’Rourke报告NFP有减弱心肌收缩力的作用。在全身给药时,这种作用被周围血
Nifedipine (nifedipine, NFP) is a widely used calcium antagonist, initially used for the treatment of angina pectoris, hypertension, congestive heart failure (heart failure) and so on. Has been developed for the treatment of bronchial asthma, Ray’s disease, urinary tract obstruction, migraine, abdominal pain, peptic ulcer, protect liver cells, inhibit uterine contractions. However, this product also has some side effects, some symptoms, signs are more serious. This article synthesis of the literature on the side effects of NFP described below. First, induce and aggravate heart failure Robson reported a case of patients with recumbent angina, a year ago, anterior parietal subendocardial infarction, cast atenolol, heartburn and NFP 2 weeks after the occurrence of subendocardial infarction , Dyspnea and pulmonary blood stagnation, cardiothoracic ratio of 16/30, given diuretic calming gradually disappear after 5 days of patients with significant heart failure, lung and peripheral edema. Needle diuretic therapy, 4 months after deactivation of NFP heart failure did not develop, and then NFP20 mg, 3 times a day re-treatment, 3 days after withdrawal due to aggravating angina and difficulty breathing, and then improve the symptoms. Coloucci and O’Rourke report NFP has the effect of reducing myocardial contractility. When administered systemically, this effect is caused by the peripheral blood