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目的探讨本地区体检人群幽门螺杆菌(helicobacter pylori,Hp)感染状况与脂代谢异常的关系。方法2366例健康体检者以~(14)C尿素呼气试验(~(14)C urea breath test,~(14)C-UBT)检测了Hp感染的情况,分析体检人群Hp感染的性别、年龄分布特点。~(14)C-UBT值≥100dpm/mmol CO_2为Hp阳性的判断标准,分为Hp阳性组(n=691)和Hp阴性组(n=1675),比较2组血清总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)及高密度脂蛋白(high-density lipoprotein,HDL)水平以及血脂异常的发生率。结果体检人群总体Hp感染率为29.21%,男性28.46%,女性30.14%,性别间差异无统计学意义(P>0.05)。各年龄段Hp感染率不同,差异具有统计学意义(P<0.05);40~49岁组感染率为35.18%,明显高于总体水平。20~29岁组Hp感染率为22.16%,明显低于总体水平。Hp阳性组血脂异常发生率与Hp阴性组比较差异无统计学意义(P>0.05)。结论 Hp感染与血脂异常的关系尚不明确,有待深入研究。
Objective To investigate the relationship between Helicobacter pylori (Hp) infection and abnormal lipid metabolism in medical examination population in the region. Methods 2366 healthy subjects were tested for Hp infection by ~ (14) C urea breath test and ~ (14) C-UBT. The gender and age of Hp infection Distribution characteristics. Hb positive group (n = 691) and Hp negative group (n = 1675), the total cholesterol (total cholesterol, TC, triglyceride (TG) and high-density lipoprotein (HDL) levels and the incidence of dyslipidemia. Results The prevalence of Hp infection was 29.21%, 28.46% in males and 30.14% in females. There was no significant difference between the sexes (P> 0.05). The infection rate of Hp in different age groups was different, the difference was statistically significant (P <0.05). The infection rate in 40-49 group was 35.18%, which was obviously higher than the overall level. The prevalence of Hp in 20-29 age group was 22.16%, which was significantly lower than the overall level. The incidence of dyslipidemia in Hp positive group was not significantly different from that in Hp negative group (P> 0.05). Conclusion The relationship between Hp infection and dyslipidemia is not yet clear and needs further study.