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本文从药品鉴别的角度出发,首先论述了拉曼光谱分析技术并测试了九种针剂药品的拉曼光谱,通过分析讨论相关药品的拉曼光谱得出了几点结论:(1)某些药品的拉曼峰较多,特征峰值较强,频移范围比较广,例如:氟尿嘧啶,依托泊苷,异烟肼,克林霉素磷酸酯。(2)某些药品拉曼峰较弱,或是没有明显的特征峰,例如:硫酸阿米卡星,甲氧苄啶,利巴韦林,葡萄糖依诺沙星,硫酸庆大霉素。(3)在分析频率及其相对强度时发现,在某一频率下正对的峰高和面积较大,则其相对强度较大,例如:氟尿嘧啶,异烟肼,硫酸阿米卡星,甲氧苄啶,葡萄糖依诺沙星。虽然得到的结论还不能满足对药品的品质鉴定,但通过拉曼光谱分析技术在药品鉴别中的应用,给出了一些药品的拉曼特征谱,为药品的鉴别提供了参考依据。可以说利用光谱分析技术对药品进行鉴别是完全可行的。
This article from the drug identification point of view, first of all, Raman spectroscopy techniques discussed and tested nine kinds of injection drug Raman spectrum, by analyzing and discussing the Raman spectrum of related drugs reached a few conclusions: (1) Certain drugs Of the Raman peaks are more characteristic peaks stronger, a wider range of frequency shift, such as: fluorouracil, etoposide, isoniazid, clindamycin phosphate. (2) Raman peaks of some drugs are weaker or have no obvious characteristic peaks, such as amikacin sulfate, trimethoprim, ribavirin, gluconate enoxacin, gentamicin sulfate. (3) When analyzing the frequency and its relative intensity, it is found that the relative intensity is larger when the peak height and the area are opposite at a certain frequency, for example, fluorouracil, isoniazid, amikacin sulfate, Oxybenzidine, Enoxacin Glucose. Although the conclusions obtained still can not meet the quality identification of drugs, the Raman spectrum of some drugs is given through the application of Raman spectroscopy in drug identification, which provides a reference for the identification of drugs. It can be said that the use of spectral analysis of drugs to identify is entirely feasible.