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目的通过定量测定孕妇早期妊娠血清中的可溶性人白细胞抗原G(sHLA-G)的表达,探讨sHLA-G的表达水平与妊娠结局的关系。方法收集35例孕30d左右孕妇,20例未孕妇女外周血清,采用ELISA法定量检测样本中sHLA-G的表达;比较早期妊娠、早期自然流产和未孕妇女三组sHLA-G的表达水平。结果早期妊娠组血清中sHLA-G的表达水平为(62.35±1.02)U/mL,原因不明性流产组为(27.74±0.95)U/mL,未孕组为(20.56±0.79)U/mL,其中早期妊娠组血清中sHLA-G的表达水平高于原因不明性流产组(P<0.01)和未孕组(P<0.01),差异有显著性。结论妊娠早期孕妇血清中sHLA-G与妊娠成功有直接关系,sHLA-G降低可能会导致原因不明性流产的发生。
Objective To investigate the relationship between sHLA-G expression and pregnancy outcome by quantitative determination of soluble human leukocyte antigen G (sHLA-G) in early pregnant women. Methods Serum levels of sHLA-G in 35 pregnant women and 20 pregnant women were detected by ELISA. The expression of sHLA-G in early pregnancy, early spontaneous abortion and non-pregnant women was compared. Results The serum levels of sHLA-G in early pregnancy were (62.35 ± 1.02) U / mL, (27.74 ± 0.95) U / mL in unexplained abortion group and (20.56 ± 0.79) U / The serum levels of sHLA-G in early pregnancy group were significantly higher than those in unexplained abortion group and non-pregnant group (P <0.01). Conclusion Serum sHLA-G in early pregnancy is directly related to the success of pregnancy. The decrease of sHLA-G may lead to unexplained abortion.