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目的:建立丙戊酸镁片含量及溶出度的GC测定方法.方法:采用GC内标法测定丙戊酸镁片的含量及溶出度;含量测定用样品采用0.1 mol·L-1盐酸溶液溶解,用二氯甲烷进行萃取,以正二十烷为内标.溶出度采用中国药典2015年版溶出度第一法转篮法,以0.1 mol·L-1盐酸溶液600 ml作为溶出介质,转速为100 r·min-1,于45 min取样,续滤液用二氯甲烷萃取,以正二十烷为内标.结果:丙戊酸镁的浓度在0.005~1.000 mg·ml-1范围内,呈良好的线性关系(r=0.9999),平均回收率为99.2%,平均RSD为0.5%(n=9).溶出度测定结果显示,45 min内丙戊酸镁片溶出量在80%以上.结论:本文所采用的测定方法专属性好,准确度高,可同时用于测定丙戊酸镁片含量及溶出度.“,”Objective: To establish a GC determination method for the content and dissolution of magnesium valproate tablets. Methods:Magnesium valproate tablets were detected by a GC internal standard method. The samples were dissolved in 0. 1 mol·L-1 hydrochloric acid solution, and then extracted by dichloromethane. Eicosane was used as the internal standard. The dissolution was de-termined by the first method described in ChP 2015 edition. The dissolution medium was 0. 1 mol·L-1 hydrochloric acid solution and the rotation speed was 100 r·min-1 with the sampling time at 45 min. The samples were extracted by dichiormethane, and eicosane was used as the internal standard as well. Results: The dissolution of magnesium valproate tablets showed good linearity within the range of 0. 005-1. 000 mg·ml-1(r=0. 9999). The recovery was 99. 2% (RSD=0. 5%, n=9). The dissolution curve showed that magnesium valproate released above 80% in 45 minutes. Conclusion:The method has good specificity and high accuracy, and can be used for the content determination and dissolution detection of magnesium valproate tablets.