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目的 探讨 CD1 5S和 E-上皮钙粘附素 (E- cadherin,ED)表达与肺癌转移和预后的关系。方法 应用免疫组化方法检测 6 5例肺癌组织中 CD1 5S及 ED蛋白表达 ,结合临床病理指标及随访资料分析。结果 在肺癌中 CD1 5S和 ED阳性表达率分别为 6 7.7%和 5 3.8%。 CD1 5S高表达和 ED低表达与肺癌组织类型、PTNM分期、病理分级、淋巴结转移和患者 >5年生存率相关 (P<0 .0 5 )。 CD1 5S表达与 ED表达呈负相关 (r=- 0 .4 4 ,P<0 .0 0 1)。结论 CD1 5S和 ED表达均可作为预测肺癌转移和评估预后的参考指标
Objective To investigate the relationship between the expression of CD15S, E-cadherin (ED) and the metastasis and prognosis of lung cancer. Methods The expressions of CD15S and ED in 65 cases of lung cancer tissues were detected by immunohistochemistry. Combined with clinicopathological parameters and follow-up data analysis. Results The positive rates of CD15S and ED in lung cancer were 6 7.7% and 53.8% respectively. The high expression of CD15S and the low expression of ED correlated with the histological type of lung cancer, PTNM stage, pathological grade, lymph node metastasis and the 5-year survival rate of patients (P <0.05). CD1 5S expression was negatively correlated with ED expression (r = - 0.44, P <0.001). Conclusions The expression of CD15S and ED can be used as a reference index for predicting lung cancer metastasis and prognosis