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目的探讨血浆N-末端脑钠肽(NT-ProBNP)水平与心力衰竭程度的相关性。方法选择器质性心脏病心力衰竭患者443例(心力衰竭组)和同期住院的无器质性心脏病患者110例(对照组)作为研究对象,采用电化学发光全自动免疫分析仪测定两组患者血浆NT-ProBNP水平,评价NT-ProBNP水平与心力衰竭及心血管事件发生的关系。结果心力衰竭组NT-ProBNP水平显著高于对照组(P<0.05);且心力衰竭患者的NYHA心功能分级越高,NT-ProBNP水平越高(P<0.05),再发心血管事件发生率也越高。结论 NT-ProBNP在心力衰竭临床诊断、心功能分级及预后评估中具有重要的地位和价值,可作为监测心功能的良好指标。
Objective To investigate the relationship between plasma N-terminal brain natriuretic peptide (NT-ProBNP) and the degree of heart failure. Methods 443 patients with heart failure (HF) and 110 patients without organic heart disease (control group) were enrolled in this study. Electro-chemiluminescence immunoassay Patients with plasma NT-ProBNP levels, evaluation of NT-ProBNP levels and heart failure and cardiovascular events. Results The level of NT-ProBNP in heart failure group was significantly higher than that in the control group (P <0.05). The NYHA functional class was higher in patients with heart failure, the higher the level of NT-ProBNP was (P <0.05), and the incidence of recurrent cardiovascular events Also higher. Conclusion NT-ProBNP plays an important role in the clinical diagnosis, cardiac function classification and prognosis evaluation of heart failure, and can be used as a good indicator to monitor heart function.