目的观察前列腺素E1联合低分子右旋糖酐治疗肝硬化难治性腹水疗效。方法肝硬化难治性腹水患者64例随机平均分为两组。对照组常规护肝、利尿、补充白蛋白和血浆;治疗组除白蛋白外在对照组的基础上加用前列腺素E1和低分子右旋糖酐。结果治疗组腹水得到很好的消退,与对照组相比差异有显著意义(P<005)。结论前列腺素E1和低分子右旋糖酐可起到扩充血容量、提高血浆胶体渗透压、改善微循环、使肾血流量增加和促进利尿排钠的作用,可使肝硬化难治性腹水得到很好的消退。 Objective To observe the efficacy of prostaglandin E1 combined with low molecular weight dextran in the treatment of refractory cirrhosis and ascites. Methods 64 patients with cirrhosis and refractory ascites were randomly divided into two groups. In the control group, routine liver protection, diuresis, albumin and plasma were added. In the treatment group, prostaglandin E1 and low molecular weight dextran were added to the control group on the basis of albumin. Results Ascites of the treatment group was well resolved, with significant difference compared with the control group (P <005). Conclusion Prostaglandin E1 and low molecular weight dextran can play a role in expanding blood volume, increasing plasma colloid osmotic pressure, improving microcirculation, increasing renal blood flow and promoting diuretic sodium release, which can make cirrhosis refractory ascites well Faded