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目的探讨血清癌胚抗原(CEA)、糖类抗原19-9(CA19-9)及糖类抗原72-4(CA72-4)联检在胃癌诊断中的价值。方法用电化学发光法检测胃癌患者、胃良性疾病患者和健康对照组血清CEA、CA19-9及CA72-4水平。结果胃癌患者血清中三种肿瘤标志物阳性检出率均高于胃良性疾病组(P<0.05)和健康对照组(P<0.01)。胃癌患者TNM分期越高,其血清中三种肿瘤标志物的水平也越高。结论 CEA、CA19-9及CA72-4是胃癌患者血清学诊断较好的肿瘤标志物,三者联合检测可提高胃癌诊断的敏感性和特异性。
Objective To investigate the value of serum carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9) and carbohydrate antigen 72-4 (CA72-4) in the diagnosis of gastric cancer. Methods The levels of serum CEA, CA19-9 and CA72-4 in patients with gastric cancer, benign gastric diseases and healthy controls were detected by electrochemiluminescence. Results The positive rate of three tumor markers in gastric cancer patients was higher than that in benign gastric disease group (P<0.05) and healthy control group (P<0.01). The higher the TNM stage of gastric cancer patients, the higher the level of the three tumor markers in the serum. Conclusion CEA, CA19-9 and CA72-4 are good tumor markers for gastric cancer patients. The combination of CEA, CA19-9 and CA72-4 can improve the sensitivity and specificity of gastric cancer diagnosis.