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目的观察硝苯地平缓释片联合依那普利治疗老年高血压病的临床疗效。方法将100例老年高血压患者随机分为两组比较疗效。硝苯地平缓释片联合依那普利组治疗组50例,单用依那普利组对照组50例,观察疗效,并观察对心率、血脂、血糖、肾功能的影响。结果治疗组显效45例,有效3例,无效2例,总有效率96.0%;对照组显效24例,有效16例,无效10例,总有效率80.0%;两组间比较差异有统计学意义。两组治疗前后心率、血脂、血糖、肾功能无明显变化。结论硝苯地平缓释片联合依那普利在取得较理想降压效果的同时,对心率、血脂、血糖、肾功能均无明显影响,值得临床推广使用。
Objective To observe the clinical efficacy of nifedipine sustained-release tablets combined with enalapril in the treatment of elderly patients with essential hypertension. Methods One hundred elderly patients with hypertension were randomly divided into two groups. 50 cases of nifedipine combined with enalapril group and 50 cases of enalapril alone group were used to observe the effect of heart rate, blood lipid, blood glucose and renal function. Results In the treatment group, 45 cases were markedly effective, 3 cases were effective, 2 cases were ineffective and the total effective rate was 96.0%. In the control group, 24 cases were markedly effective, 16 cases were effective, 10 cases were ineffective and the total effective rate was 80.0%. There was significant difference between the two groups . Before and after treatment, heart rate, blood lipid, blood glucose, renal function no significant change. Conclusions Nifedipine sustained-release tablets combined with enalapril have no significant effect on heart rate, blood lipid, blood glucose and renal function, which is worthy of clinical promotion and use.