脂肪萎缩性糖尿病(LD)是一种罕见的疾病,有特征性体态并伴有严重的糖和脂类代谢异常。患者皮下脂肪缺如、有高血糖和高甘油三酯血症并常对胰岛素作用抵抗。LD 病因曾被认为是由于下丘脑/垂体轴的功能紊乱。但从 LD 中看到:在睡眠慢波期及用精氨酸或胰岛素刺激后生长激素不释放,在周围血浆中可测到肾上腺皮质激素、卵泡刺激素及黑色素细胞刺激激素释放因子;在尿里有一种能动员脂类的肽,用中枢性多巴胺能阻断剂 Lipoatrophic diabetes (LD) is a rare condition characterized by a characteristic body with severe metabolic abnormalities of sugar and lipid. Patients with subcutaneous fat absent, with hyperglycemia and hypertriglyceridemia and often resistant to insulin action. The cause of LD was thought to be due to dysfunction of the hypothalamus / pituitary axis. However, seen from the LD: in slow wave sleep period and with arginine or insulin stimulation after the release of growth hormone in the peripheral plasma can be measured in the adrenal cortex hormones, follicle stimulating hormone and melanocyte stimulating hormone releasing factor; in urine There is a peptide that can mobilize lipids, using central dopamine blockers