目的探讨热化疗对于晚期卵巢癌的近期治疗效果,3年生存率和毒副反应的影响。方法44例晚期卵巢癌患者均经过手术病理分期,随机分成热化疗组和化疗组,比较两组的近期疗效,3年生存率和毒副反应的发生率。结果热疗组的近期疗效明显高于化疗组(P<0.05)。热疗组的3年生存率为65%高于化疗组(48%),但没有统计学上的差异。两组毒副反应的发生率相似,症状轻微,可以耐受。结论热化疗治疗卵巢癌患者有好的近期疗效,毒副反应小,有望提高晚期卵巢癌患者的5年生存率。 Objective To investigate the effect of thermochemotherapy on the treatment of advanced ovarian cancer, 3-year survival rate and toxicity. Methods Forty-four patients with advanced ovarian cancer were divided into two groups according to the pathological staging. The curative effect, 3-year survival rate and the incidence of adverse reactions were compared between the two groups. Results The short-term curative effect of hyperthermia group was significantly higher than that of chemotherapy group (P <0.05). The 3-year survival rate of hyperthermia group was 65% higher than that of chemotherapy group (48%), but there was no statistical difference. The incidence of toxic and side effects in both groups was similar with mild symptoms and could be tolerated. Conclusions The thermochemotherapy for patients with ovarian cancer has a good short-term curative effect with little toxic side effects and is expected to improve the 5-year survival rate of patients with advanced ovarian cancer.