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β受体阻滞剂的降压机制足减少心排血量。但不改变外周血量阻力,而α受体阻滞剂能使血压下降但心排血量却反射增加了。因此著者设想联合使用α、β受体阻滞剂应能产生协同的降压作用。著者观察了12名原发性高血压患者在静止和活动期(次极量脚踏车试验Submaximal bicycle exerclse)的血液动力学改变。把这12名患者分为两组:第一组患者在对照研究之后,给予静脉滴注酚妥拉明
Antihypertensive mechanism of beta blockers can reduce cardiac output. But does not change the resistance of peripheral blood, and α-blockers can make blood pressure decreased but cardiac output increased. Therefore, the authors envisage the combination of α, β blockers should be able to produce a synergistic antihypertensive effect. The authors observed hemodynamic changes in resting and active (Submaximal bicycle exerclse) in 12 patients with essential hypertension. The 12 patients were divided into two groups: the first group of patients in the control study, given intravenous infusion of phentolamine