论文部分内容阅读
随着基因治疗技术的不断发展，越来越多的新技术被逐步应用于疾病的实验室研究和临床治疗中。在艾滋病的治疗中，基因治疗技术相较于传统的抗病毒逆转录治疗有明显优势。近年来，短发夹RNA(short hairpin RNA, shRNA)技术、成簇规律间隔短回文重复序列(clustered regulatory interspaced short palindromic repeat, CRISPR)技术、类转录激活因子效应物核酸酶(transcription activator-like effector nucleases, TALEN)技术、锌指核酶(zinc finger nucleases, ZFN)技术等基因治疗技术在艾滋病治疗中的应用已经取得较多成果。本文综述了自基因治疗技术出现以来在艾滋病治疗领域的重大突破，以及近年来所取得的最新研究进展，旨在为该技术在艾滋病治疗中的更广泛应用提供参考。“,”With the continuous development of gene therapy, more new technologies have been found and gradually applied in the basic research and clinical treatment of various diseases. In the field of AIDS treatment, gene therapy shows obvious advantages over traditional antiretroviral therapy. In recent years, short hairpin RNA (shRNA), clustered regulatory interspaced short palindrome repeat (CRISPR), transcription activator-like effector nucleases (TALEN), and zinc finger nucleases (ZFN) have been applied in AIDS treatment and have fruitful results. This paper reviews the major breakthroughs in this field since the emergence of gene therapy and the latest research achievements and their progress, with a view to providing a useful reference on a wider range of gene therapy application.