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MEKK3(MAP kinase kinase kinases 3)是丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPK)信号转导通路中的重要节点,与恶性肿瘤密切相关,是近年来恶性肿瘤的研究热点。本文就MEKK3在信号转导通路中的表达机制及其与恶性肿瘤的关系、研究进展做了综述。1MEKK3的分子结构特征MEKK3是MAPK家族中的重要成员,其分子量约为78～80kDa,编码MEKK3的mRNA的分子大小约为
MEKK3 (MAP kinase kinase kinases 3) is an important node in the mitogen-activated protein kinases (MAPK) signal transduction pathway. It is closely related to malignant tumors and is a research hotspot of malignant tumors in recent years. This article reviews the mechanism of MEKK3 expression in the signal transduction pathway and its relationship with malignant tumors and research progress. Molecular Structure of 1MEKK3 MEKK3 is an important member of the MAPK family. Its molecular weight is approximately 78 to 80 kDa, and the molecular size of the mRNA encoding MEKK3 is approximately