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目的探讨尿激酶溶栓在急性心肌梗死中的治疗效果。方法选取2012-11—2015-03就诊于新疆阿克苏地区第一人民医院CCU急性心肌梗死患者81例,按是否溶栓将患者分为对照组42例和尿激酶组39例,对照组按急性心肌梗死常规治疗,尿激酶组在常规治疗基础上,采用尿激酶溶栓治疗。尿激酶组中按发病至溶栓时间分为6h之内溶栓组25例和6-12h内溶栓组14例。分别比较对照组与尿激酶组、6h之内溶栓组和6-12h内溶栓组的冠脉再通率。结果尿激酶组的冠脉再通率为54%,明显高于对照组的12%,两组差异有统计学意义(X~2=16.31,p<0.05);尿激酶组中,发病至溶栓时间6h之内的冠脉再通率为68%,明显高于发病至溶栓时间6-12h内的29%,两组差异有统计学意义(X~2=5.61,p<0.05)。结论尿激酶溶栓是早期急性心肌梗死有效的治疗方法,发病至溶栓时间越早,冠脉再通率越高,值得临床推广。
Objective To investigate the therapeutic effect of urokinase thrombolysis in acute myocardial infarction. Methods A total of 81 patients with acute myocardial infarction (CCU) admitted to the First People’s Hospital of Aksu, Xinjiang from 2012-11-2015-03 were divided into 42 cases of control group and 39 cases of urokinase group by thrombolytic therapy. The patients in control group were treated with acute myocardial infarction Conventional treatment of infarction, urokinase group based on conventional treatment, the use of urokinase thrombolysis. Urokinase group according to onset to thrombolytic time is divided into 6h within 25 cases of thrombolytic group and 6-12h within thrombolytic group of 14 cases. The rates of coronary recanalization were compared between the control group and urokinase group, within 6 hours of thrombolysis group and within 6-12 hours of thrombolysis group. Results The rate of coronary recanalization in urokinase group was 54%, which was significantly higher than that in control group (X ~ 2 = 16.31, p <0.05). In urokinase group, The rate of coronary recanalization within 6 hours after embolization was 68%, which was significantly higher than 29% within 6-12 hours after onset of thrombolysis. The difference between the two groups was statistically significant (X ~ 2 = 5.61, p <0.05). Conclusions Urokinase thrombolysis is an effective treatment for early acute myocardial infarction. The earlier the thrombolysis time is, the higher the recanalization rate of coronary artery is, which is worthy of clinical promotion.