【摘 要】
：
A new series of polyamine-toxic cargo conjugates was synthesized with aryl aldehydes conjugating to hydrazino-containing triamine skeletons.The in vitro cytotox
【机 构】
：
Key Lab of Natural Medicinal and Immunotechnology of Henan Province
论文部分内容阅读
A new series of polyamine-toxic cargo conjugates was synthesized with aryl aldehydes conjugating to hydrazino-containing triamine skeletons.The in vitro cytotoxicity of target compounds was evaluated in several cancer cell lines (e.g.,L1210,HeLa and B16) and the cellular entry of these polyamine conjugates via polyamine transporter was investigated on SPD- or DFMO-treated B16 cell line.Of these compounds,6c show significant cytotoxicity on L1210,HeLa and B 16 cell lines (ICs0 value,3.74 μmol/L,5.66 μmol/L and 4.04 μmol/L,respectively).The polyamine transporter assay demonstrated the suitability of hydrazino-containing polyamine backbones for application as vectors in drug delivery systems.
其他文献
The authors prove the certain de Leeuw type theorems on some non-convolution operators, and give some applications on certain known results.
Synthetic studies on the construction of 7-O-methylquercetin from quereetin in 36% yield in four steps is reported, this strategy relies on one hand on the sele
In this article, we give sufficient conditions for controllability of some partial neutral functional differential equations with infinite delay. We suppose tha
The complexity of decoding the standard Reed-Solomon code is a well-known open problem in coding theory. The main problem is to compute the error distance of a
In this article, we give the area formula of the closed projection curve of a closed space curve in Lorentzian 3-space L3. For the 1-parameter closed Lorentzian
By using the index theory for linear bounded self-adjoint operators in a Hilbert space related to a fixed self-adjoint operator A with compact resolvent, the au
Crystal structure and some dynamic performances of Ti0.25V0.34Dy0.01Cr0.1Ni0.3 hydrogen storage electrode alloy have been investigated by XRD,FESEM-EDS,TEM and
With dimethylamine as a template, a new one-dimensional zincophosphite (C2H8N)·[Zn(HPO3)(H2PO3)]was prepared under hydrothermal conditions and characterized by
The author investigated the antioxidant effect of irbesartan[2-butyl-3-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1,3-diazaspiro[4.4]non-1-en-4-one]
The asymptotic behavior at infinity and an estimate of positive radial solutions of the equation△u+kΣi=1cirliupi=0,x∈Rn,are obtained and the structure of sep