1955年Zollinger和Ellison首先报告2个病例,其主要特征是:(1)暴发性溃疡体质;(2)胃酸分泌亢进:(3)胰岛有非β细胞瘤。1956年Eiseman称本病为卓-艾(Zollinger Ellison)综合征。以后的研究阐明,本病的病因是由于肿瘤分泌胃泌素,故最近多称本病为胃泌素瘤。多发性内分泌腺瘤I型(除有胰腺肿瘤以外,尚在甲状旁腺、脑下垂体、肾上腺等处有肿瘤或细胞增殖)48％以上伴有卓-艾综合征,而多发性内分泌腺瘤Ⅱ型(有嗜铬细胞瘤、甲状腺髓样癌、甲状旁 In 1955 Zollinger and Ellison first reported two cases, the main features are: (1) the constitution of fulminant ulcer; (2) hyperacidity of gastric acid secretion: (3) pancreatic islet cell tumors. 1956 Eiseman said the disease is Zollinger Ellison syndrome. After the study shows that the etiology of the disease is due to tumor secretion of gastrin, it recently said the disease is gastrinoma. Multiple endocrine neoplasia type I (with the exception of pancreatic tumors, but also in the parathyroid, pituitary gland, adrenal gland, etc. there are tumor or cell proliferation) with more than 48% Zhuo - Ai syndrome, and multiple endocrine neoplasia Type Ⅱ (pheochromocytoma, medullary thyroid carcinoma, parathyroid