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干扰素(Interferon,IFN)是一类具有抗病毒、免疫调节、抑制细胞增殖等多种生物活性的细胞因子,而体内循环半衰期短限制了其在临床上的应用。聚乙二醇(Polyethylene glycol,PEG)修饰可以有效地改善干扰素的理化性质和生物学特性,延长体内循环半衰期。本文综述了聚乙二醇修饰干扰素的研究进展,着重介绍了聚乙二醇修饰化学的发展,α、β、γ干扰素各自不同的聚乙二醇化学修饰方法,并对聚乙二醇化干扰素的发展趋势进行了展望。
Interferon (IFN) is a class of cytokines with many biological activities such as anti-virus, immunomodulatory, and inhibition of cell proliferation. The short circulating half-life in vivo limits its clinical application. Polyethylene glycol (PEG) modification can effectively improve the physical and chemical properties of interferon and biological characteristics, to extend the circulatory half-life in vivo. This review summarizes the research progress of PEG-modified IFNs, and focuses on the development of PEG-modified chemicals, the different PEGylation of α, β, and IFN-γ, and the modification of PEGylation Prospects for the development of interferon are prospected.