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【目的】了解病毒和肺炎支原体病原在宝鸡地区小儿急性下呼吸道感染(acute lower respiratory infec-tions,ALRI)患儿中的构成特点。【方法】收集宝鸡市5家医院2010年8月-2011年7月ALRI住院小儿7 979例的病毒和肺炎支原体病原学检测结果进行汇总分析。【结果】小儿ALRI患儿血清7种急性病毒抗体IgM总阳性率为32.7%;阳性率由高到低依次为:EB病毒抗衣壳抗原抗体IgM 7.6%,柯萨奇病毒抗体IgM 7.2%,巨细胞病毒抗体IgM5.5%,埃可病毒抗体IgM 5.1%,副流感病毒抗体IgM 4.1%,腺病毒抗体IgM 2%,呼吸道合胞病毒抗体IgM 1.2%。肺炎支原体抗体IgM阳性率12.6%。下呼吸道分泌物病原核酸(PCR-荧光探针法)检测阳性率结果为:EB病毒DNA24.4%,肠道病毒(普通型)RNA 10.7%,呼吸道合胞病毒RNA 4.3%,柯萨奇病毒A 16 3.8%;肺炎支原体核酸定量阳性率为11.7%。临床最常见的混合感染是EBV和MP混合感染。【结论】小儿ALRI病原学分布存在人群、地区和季节、年份等的差异性,病毒和肺炎支原体是宝鸡地区小儿ALRI的重要病原,病毒以EBV为主。应开展多方法、多病原的联合检测。
【Objective】 To understand the characteristics of viruses and Mycoplasma pneumoniae pathogens in children with acute lower respiratory infection (ALRI) in Baoji area. 【Method】 A total of 7 979 cases of children with ALRI hospitalized in 5 hospitals in Baoji between August 2010 and July 2011 were collected for pathogenicity analysis of mycoplasma pneumoniae. 【Results】 The positive rate of IgM in seven kinds of acute virus antibodies in children with ALRI was 32.7%. The positive rates of anti-capsid antigen antibody (EBM) were IgM 7.6%, Coxsackie virus IgM 7.2% Cytomegalovirus antibody IgM5.5%, echovirus antibody IgM 5.1%, parainfluenza virus IgM 4.1%, adenovirus antibody IgM 2%, respiratory syncytial virus IgM 1.2%. Mycoplasma pneumoniae antibody IgM positive rate of 12.6%. The positive rate of detection of lower respiratory secretions nucleic acid (PCR-fluorescence probe method) results: 24.4% of EB virus DNA, 10.7% of enterovirus (ordinary type) RNA, 4.3% of respiratory syncytial virus RNA, Coxsackie virus A 16 3.8%; Mycoplasma pneumoniae nucleic acid quantitative positive rate was 11.7%. The most common clinical mixed infection is EBV and MP mixed infection. 【Conclusion】 The distribution of ALRI in children has different population, region, season, year and so on. Viruses and Mycoplasma pneumoniae are important pathogens of ALRI in infants in Baoji region. The virus is mainly EBV. Should carry out multi-method, multi-pathogenic joint detection.