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目的探讨乳腺癌患者化疗后肺部感染与复发转移相关指标的变化,为患者治疗干预措施的制定提供依据。方法选取2013年1月-2015年10月45例乳腺癌化疗后肺部感染患者为A组,并选取同时间段内化疗后未发生感染的45例患者为B组,45例单纯肺部感染患者为C组,比较3组患者临床指标,数据采用SPSS 16.0软件进行统计分析。结果 A组患者血清肿瘤标志物包括CA125、CA153、CA199及CEA水平分别为(21.45±2.25)U/ml、(18.51±1.84)U/ml、(19.56±2.24)U/ml及(5.58±0.46)ng/ml,均高于B组及C组;A组的血清VEGF相关指标及MMP相关指标均高于B组及C组,且A组中轻度、中度及重度肺部感染患者的上述血清指标差异均有统计学意义(P<0.05)。结论乳腺癌化疗后肺部感染患者复发转移相关指标的变化明显,且肺部感染的严重程度对其血清水平也存在较大的影响,因此应重视对乳腺癌患者化疗后肺部感染的控制。
Objective To investigate the changes of lung infection and recurrence and metastasis after chemotherapy in patients with breast cancer and provide the basis for the development of therapeutic interventions. Methods From January 2013 to October 2015, 45 patients with lung infection after breast cancer chemotherapy were selected as group A, and 45 patients without infection after chemotherapy during the same period were selected as group B and 45 patients with simple lung infection The patients were in group C, and the clinical indexes of three groups were compared. The data were analyzed by SPSS 16.0 software. Results The serum levels of CA125, CA153, CA199 and CEA in group A were 21.45 ± 2.25 U / ml, 18.51 ± 1.84 U / ml, 19.56 ± 2.24 U / ml and 5.58 ± 0.46 ) ng / ml were higher than those in group B and group C. Serum levels of VEGF and MMP in group A were higher than those in group B and group C, and those in group M with mild, moderate and severe pulmonary infections The above serum indicators were statistically significant (P <0.05). Conclusions The index of recurrence and metastasis of patients with pulmonary infection after breast cancer chemotherapy changes obviously. And the severity of pulmonary infection has a significant impact on the serum level. Therefore, we should pay more attention to the control of lung infection after chemotherapy in patients with breast cancer.