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目的:探讨糖尿病肾病患者血清转铁蛋白(Transferrin,TRF)和视黄醇结合蛋白(retinolbinding protein,RBP)的检测及其临床意义。方法:将100例2型糖尿病患者(包括单纯糖尿病45例、糖尿病肾病55例)依据其尿蛋白定性试验分为尿蛋白阳性组和阴性组,用免疫透射比浊法测量上述2种TRF、RBP及血清尿素(Urea)水平,并与对照组进行比较。结果:糖尿病尿蛋白阳性组和阴性组的TRF和RBP水平均明显高于对照组,且糖尿病尿蛋白阳性组的这2种微量蛋白水平又明显高于尿蛋白阴性组,差异均有显著意义(P<0.01);单纯糖尿病及糖尿病肾病患者尿TRF、尿及血清RBP浓度明显高于对照组(P<0.01)。糖尿病肾病患者随着病情进展,TRF、RBP浓度逐渐升高。结论:TRF及RBP是较敏感的肾功能指标,可作为糖尿病肾病的早期诊断和监测指标。
Objective: To investigate the detection of serum transferrin (TRF) and retinol binding protein (RBP) in patients with diabetic nephropathy and its clinical significance. Methods: 100 type 2 diabetic patients (including 45 cases of simple diabetes mellitus and 55 cases of diabetic nephropathy) were divided into urinary protein positive group and negative group according to their urinary protein qualitative test. The levels of TRF, RBP And serum urea (Urea) levels, and compared with the control group. Results: The levels of TRF and RBP in diabetic urinary protein positive group and negative group were significantly higher than those in control group, and the levels of these two micro-proteins in diabetic urine protein positive group were significantly higher than those in negative urine protein group P <0.01). Urinary TRF, urinary and serum RBP concentrations in patients with simple diabetes and diabetic nephropathy were significantly higher than those in the control group (P <0.01). Patients with diabetic nephropathy as the disease progresses, TRF, RBP concentration gradually increased. Conclusion: TRF and RBP are more sensitive indicators of renal function, which can be used as an early diagnosis and monitoring index of diabetic nephropathy.