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膜增生性肾炎是一种有特殊形态结构的原发性肾小球疾病,可发生于儿童及成人,其机理未明。发展为肾功能衰竭发生率高,但病程长短不一。作者介绍一种预期、随机化、双盲对照研究,对40例Ⅰ型膜增生性肾炎(系膜毛细血管性肾炎)病者给予潘生丁75mg和阿司匹林325mg,或相似的安慰药片,每天3次,饭前半小时服,连用1年。可根据病情加用抗高血压药和利尿药。有肾病综合征的病人每天摄入钠量为40～90mEq。第1年每3个月随访1次,以后每半年随访1次,共7年。结果用碘酞(iothalamate)清除率估计肾功能来评价治疗效果。没有并发症的36例坚持治疗,治疗
Membrane proliferative glomerulonephritis is a special form of structural primary glomerular disease can occur in children and adults, the mechanism is unknown. The development of high incidence of renal failure, but the duration of the disease varies. The authors describe a prospective, randomized, double-blind, controlled study in which 40 patients with type 1 mesenteric nephritis (meningococcal nephritis) were given dipyridamole 75 mg and aspirin 325 mg, or similar placebo tablets 3 times daily, Half an hour before serving, once every year. According to the disease plus antihypertensive drugs and diuretics. Patients with nephrotic syndrome daily intake of sodium 40 ~ 90mEq. The first year of follow-up every 3 months 1, followed up every six months for a total of 7 years. Results Iothalamate clearance was used to assess renal function to evaluate the therapeutic effect. 36 cases without complications adhere to treatment and treatment