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自从发现AFP,CEA等肿瘤标志物以后,肿瘤标记物的研究便引起了人们极大的兴趣,也取得了很大进展,在临床中应用最广泛的是血清,渗出液或排泄物中肿瘤标志物的检查,因为取材方便,痛苦少,便于观察对照。近来由于免疫检测技术的进步及DNA杂交、PCR技术的广泛应用,又发现许多有意义的标志物。 1 常用肿瘤标志物 1.1 癌胚抗原(CEA) 1965年由Gold et al首先自人结肠组织中发现,是胚胎性致癌抗原,正常CEA分泌入胃肠道而失去极性的癌细胞分泌CEA则进入血液和淋巴。CEA是M_r
Since the discovery of AFP, CEA and other tumor markers, the study of tumor markers has caused great interest and has made great progress. The most widely used clinically is tumors in serum, exudate or excretion. The examination of markers is easy to draw and less painful, making it easier to observe and control. Recently, due to advances in immunoassay technology and the widespread use of DNA hybridization and PCR techniques, many significant markers have been discovered. 1. Commonly Used Tumor Markers 1.1 Carcinoembryonic Antigen (CEA) was first discovered in 1965 by Gold et al. from human colon tissue. It is an embryogenic carcinogenic antigen. Normal CEA secreted into the gastrointestinal tract and loss of polar cancer cells secretes CEA. Blood and lymph. CEA is M_r