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目的观察泮托拉唑治疗十二指肠溃疡的临床疗效。方法 42例十二指肠溃疡患者随机分为2组,均给予常规治疗,治疗组22例,给予泮托拉唑40mg口服,2次/d,对照组20例,口服奥美拉唑20mg,2次/d,两组疗程均为4周,治疗过程中停服其他药物,4周后观察临床症状、溃疡愈合情况,并记录不良反应。结果治疗组治愈率为95%,对照组治愈率为91%,两组总有效率比较无显著意义(P>0.05),治疗过程中未发现严重副作用,但治疗组不良反应发生率明显低于对照组。结论两组方案治疗十二指肠溃疡均有效,泮托拉唑临床疗效优于奥美拉唑,同时不良反应少于奥美拉唑。
Objective To observe the clinical efficacy of pantoprazole in the treatment of duodenal ulcer. Methods Forty-two patients with duodenal ulcer were randomly divided into two groups. All were given conventional therapy. Twenty-two patients in the treatment group received 40 mg of pantoprazole orally twice daily for 20 days. Omeprazole 20 mg, 2 times / d, two courses of treatment were 4 weeks, stopping taking other drugs during the course of treatment, 4 weeks after the observation of clinical symptoms, ulcer healing, and record adverse reactions. Results The cure rate was 95% in the treatment group and 91% in the control group. There was no significant difference in the total effective rate between the two groups (P> 0.05). No serious side effects were found in the treatment group, but the adverse reactions in the treatment group were significantly lower than those in the control group Control group. Conclusions The two regimens are effective in treating duodenal ulcer. The clinical efficacy of pantoprazole is better than that of omeprazole, and the adverse reaction is less than that of omeprazole.