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目的:探讨冠心病患者不同胱抑素C(Cys-C)和同型半胱氨酸(Hcy)水平与冠状动脉病变程度的关系及临床意义。方法:125例经选择性冠状动脉造影确诊的冠心病患者,按Cys-C水平分为低水平(≤0.60mg/L)亚组和正常水平(≥0.60mg/L)亚组;另选32例健康者设为对照组。采集研究对象外周静脉血检测Cys-C和Hcy。冠状动脉病变按Gensini评分标准。结果:与对照组比较,低水平亚组Cys-C水平显著降低,Hcy明显增高,差异均有统计学意义(P<0.01);正常水平亚组与对照组比较,均差异无统计学意义(P>0.05)。与正常水平亚组比较,低水平亚组Cys-C水平低,Hcy水平显著增高(P<0.01),冠状动脉病变多为≥3支病变,Gensini积分高(P<0.01)。Cys-C水平与冠状动脉病变程度呈负相关(r=-0.662,P<0.01),Hcy与冠状动脉病变程度呈正相关(r=0.409,P<0.01)。结论:Cys-C和Hcy与冠状动脉病变程度密切相关。
Objective: To investigate the relationship between the levels of Cys-C and homocysteine (Hcy) and the degree of coronary artery disease in patients with coronary heart disease and its clinical significance. Methods: A total of 125 patients with coronary heart disease confirmed by selective coronary angiography were divided into two subgroups according to Cys-C level: low level (≤0.60mg / L) and normal level (≥0.60mg / L) Healthy people as a control group. Peripheral venous blood samples were collected to detect Cys-C and Hcy. Coronary lesions were grouped by Gensini score. Results: Compared with the control group, the Cys-C levels in the low-level subgroup were significantly decreased, while the Hcy levels were significantly increased (all P <0.01). There was no significant difference between the normal subgroup and the control group P> 0.05). Compared with the normal subgroup, low level subgroup Cys-C level, Hcy level was significantly increased (P <0.01), coronary artery lesions were more than 3 lesions, Gensini score was high (P <0.01). The level of Cys-C was negatively correlated with the severity of coronary artery disease (r = -0.662, P <0.01). Hcy was positively correlated with the severity of coronary artery disease (r = 0.409, P <0.01). Conclusion: Cys-C and Hcy are closely related to the severity of coronary artery disease.