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为获得更为快速的免疫应答，用３０μｇ／ｍｌ乙肝血源疫苗以０、２、６周免疫程序对６８名ＨＢｓＡｇ阳性母亲婴儿作了阻断ＨＢＶ母在传播免疫效果的观察，并与常用的０、１、６接种方案的结果进行了比较。结果表明ＨＢＩＧ合用乙肝疫苗或单用疫苗组产生抗－ＨＢｓ（＞１０ｍＩＵ／ｍｌ）．血清转换率于Ｔ（６ｍ）、Ｔ（１２ｍ）时分别为９１．８９％和８３．８７％，８１．０８％和８３．８７％。短程和常规免疫方案婴儿所产生的保护性抗－ＨＢｓ水平动态比较，表明以０、２、６周免疫后在Ｔ（６ｗ）、Ｔ（６ｍ）时的抗－ＨＢｓ有效率分别为１９．３５％和８３．８７％，明显高于０、１、６月免疫者同期抗体水平（Ｐ＜０．０１）．至Ｔ（１２ｍ）时两组的阳转率无显著性差异。说明０、２、６周免疫方案能早期诱导出保护性抗－ＨＢｓ免疫应答．
In order to obtain a more rapid immune response, 68 HBsAg positive mothers were immunized with 30μg / ml Hepatitis B vaccine for 0, 2 and 6 weeks to block the effect of HBV mother on the transmission of immunity. The results of the 0,1,6 vaccination programs were compared. The results showed that anti-HBs (> 10 mlU / ml) were produced by HBIG in combination with hepatitis B vaccine or vaccine alone. The seroconversion rate was 91.89% and 83.87%, 81.08% and 83.87% at T (6m) and T (12m), respectively. The dynamic comparison of the levels of protective anti-HBs produced by infants in short-course and routine immunizations showed that the effective rates of anti-HBs at T (6w) and T (6m) after immunization at week 0, week 2 and week 6 were 19.35 % And 83.87%, respectively, which were significantly higher than those in the same period of 0, 1 and 6 months (P <0.01). To T (12m) positive rate of the two groups no significant difference. This indicated that the 0,2,6 weeks immunization program could induce a protective anti-HBs immune response in the early stage.