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目的:探讨血清脑源性神经营养因子(BDNF)及神经元特异性烯醇化酶(NSE)检测在惊厥儿童中的临床应用价值。方法:选取该院收治的惊厥儿童40例,选取同期该院因呼吸道感染发热而住院但未见抽搐的患儿40例作为发热组,该院体检科同期健康体检40例儿童作为正常对照组,ELISA法测定3组儿童血清中BDNF及NSE水平,并比较分析。结果:惊厥组儿童的BDNF及NSE水平均高于后两组,差异均有统计学意义(P<0.05)。抽搐次数<5次组患儿血清BDNF及NSE水平显著低于抽搐次数≥5次组患儿(P<0.05),单纯性惊厥组患儿血清BDNF及NSE水平显著低于复杂性惊厥组患儿(P<0.05)。经相关性分析,BDNF与NSE水平正性相关(r=0.725,P<0.05)。结论:BDNF及NSE可预示脑组织损伤程度,且相关检测操作性强、简便易行,结果可靠,值得临床推广。
Objective: To investigate the clinical value of serum brain-derived neurotrophic factor (BDNF) and neuron-specific enolase (NSE) detection in children with convulsion. Methods Forty cases of convulsive children admitted to our hospital were enrolled in this study. Forty children with hospitalized fever but no convulsion during the same period of hospital were enrolled in this study. Forty children with normal physical examination during the same period as the normal control group, Serum levels of BDNF and NSE were measured by ELISA in three groups of children and compared. Results: The levels of BDNF and NSE in children with convulsion group were significantly higher than those in the latter two groups (P <0.05). The levels of serum BDNF and NSE in children with seizures less than 5 times were significantly lower than those in children with convulsions≥5 times (P <0.05). The levels of serum BDNF and NSE in children with convulsion group were significantly lower than those in children with complicated seizure (P <0.05). Correlation analysis showed that BDNF was positively correlated with NSE level (r = 0.725, P <0.05). Conclusion: BDNF and NSE can predict the degree of brain injury, and the relevant tests are easy to operate, reliable and worthy of clinical promotion.