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白细胞介素-10(interleukin-10，IL-10)是一种重要的抗炎因子，具有免疫调节功能。目前认为树突状细胞(dendritic cells，DCs)可以调控免疫反应，既促进免疫反应，又诱导免疫耐受。研究发现DCs是IL-10的重要细胞来源，且将产生IL-10的DCs定义为IL-10n +DCs。这群DCs通过分泌IL-10诱导免疫耐受。文章主要讨论诱导免疫耐受的IL-10n +DCs的表型、功能特征和诱导IL-10n +DCs的方法。n “,”Interleukin-10(IL-10) is a potent anti-inflammatory cytokine with immunomodulatory properties.It is reported that dendritic cells(DCs) have a capacity to regulate immune responses which can either promote immune responses or induce tolerance.Studies have shown that DCs elicit immune tolerance by secreting IL-10, and this subset of IL-10-producing DCs are defined as IL-10n + DCs.This review mainly discussed the tolerogenic properties of IL-10n + DCs and the strategies to induce IL-10n + DCs.n