论文部分内容阅读
目的 :观察慢性乙型肝炎患者血清中Ⅳ型胶原 (CⅣ )、Ⅲ型前胶原 (PCⅢ )、透明质酸 (HA)和层粘蛋白 (LN)的变化及临床意义。方法 :采用放射免疫分析对 172例受检者 (其中乙肝患者 12 9例 ,正常对照者4 3例 )血清中CⅣ、PCⅢ、HA和LN进行检测。结果 :在慢性乙肝患者血清中CⅣ、PCⅢ、HA和LN水平均较正常对照组显著升高 (p <0 0 1)。随着病程的进展 ,CⅣ、PCⅢ、HA和LN四项指标在患者血清中均呈逐渐上升趋势 ,在肝硬化时达到最高。结论 :在慢性乙型肝炎患者中 ,血清CⅣ、PCⅢ、HA和LN等指标 ,可以较好地反映肝纤维化的程度。
Objective: To observe the changes and clinical significance of serum levels of type Ⅳ collagen (Ⅳ), type Ⅲ procollagen (Ⅲ), hyaluronic acid (HA) and laminin (LN) in patients with chronic hepatitis B Methods: Serum levels of CⅣ, PCⅢ, HA and LN were detected in 172 subjects (including 129 in patients with hepatitis B and 43 in controls) by radioimmunoassay. Results: Serum levels of CⅣ, PCⅢ, HA and LN in patients with chronic hepatitis B were significantly higher than those in controls (p <0.01). As the course of disease progressed, the four indexes of CⅣ, PCⅢ, HA and LN showed a gradual upward trend in patients’ sera and reached the highest in cirrhosis. Conclusion: The serum C Ⅳ, PC Ⅲ, HA and LN in patients with chronic hepatitis B can better reflect the degree of liver fibrosis.