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目的:通过观察外用中药治疗糖尿病足临床疗效,及对患者局部组织中血管内皮细胞生长因子(VEGF)表达的影响,旨在将临床与实验数据有效结合进一步充分证明中药的有效性。方法:对照组及治疗组(各30例)均采用控制血糖、抗感染、改善血液循环等西医综合治疗措施,在此基础上对照组采用中药外用的换药方法,治疗组采用西医常规换药方法。根据溃疡面情况每日换药1次或隔日换药1次,共治疗3个月后观察两组溃疡面的愈合情况及局部组织中的VEGF表达的变化情况。结果:治疗组30例的临床疗效、溃疡愈合情况和局部组织VEGF表达均高于对照组,两组比较差异均有统计学意义。结论:中药外用能够促进创面的修复;提高局部组织的抗感染能力;上调局部组织VEGF表达,临床治疗糖尿病足,可加速溃疡愈合,提高糖尿病足坏疽的治愈率,降低致残率,取得很好的疗效。
Objective: To observe the curative effect of topical Chinese herbs on diabetic foot and its effect on the expression of vascular endothelial growth factor (VEGF) in the local tissues of patients. The purpose of this study is to validate the effectiveness of traditional Chinese medicine by combining the clinical and experimental data effectively. Methods: The control group and the treatment group (30 cases each) were used to control blood sugar, anti-infection, improve blood circulation and other Western comprehensive treatment measures, on the basis of the control group using traditional Chinese medicine dressing method, the treatment group using conventional Western dressing method. According to the situation of ulcers dressing 1 day or dressing every other day 1, a total of 3 months after the treatment of ulcer healing observed in both groups and local tissue VEGF expression changes. Results: The clinical curative effect, the healing of ulcer and the expression of VEGF in local tissue of 30 cases in the treatment group were higher than those in the control group. There were significant differences between the two groups. Conclusion: Topical application of traditional Chinese medicine can promote the repair of wounds, improve the anti-infective ability of local tissues, increase the expression of VEGF in local tissues and clinically treat diabetic foot, accelerate the healing of ulcer, improve the cure rate of diabetic foot gangrene and reduce the disability rate, Efficacy.