左旋门冬酰胺酶(L—ASP)是治疗白血病化疗药物之一。据文献报道其可引起过敏反应、肝损害、凝血障碍、胰腺炎及血糖增高。本人经管一患者应用L—ASP出现一过性血糖增高,出现糖尿病酮症酸中毒临床表现特报道如下。 患者张×,女,4 1/2岁。因间断鼻衄十余日伴周身皮肤出血点及紫癜、面色黄入院。查:贫血貌,周身散在出血点、淤斑及紫癜,四 L-asparaginase (L-ASP) is one of the chemotherapeutic agents for the treatment of leukemia. It has been reported in the literature can cause allergic reactions, liver damage, coagulation disorders, pancreatitis and increased blood sugar. I administered a patient with L-ASP appeared transient increase in blood glucose, diabetic ketoacidosis clinical manifestations are reported as follows. Patient ×, female, 4 1/2 years old. Due to intermittent epistaxis ten days with peripheral skin bleeding and purpura, looking yellow hospital. Check: anemia appearance, whole body scattered in the bleeding point, ecchymosis and purpura, four