论文部分内容阅读
本文报道60只家兔中的40只感染血吸虫尾蚴形成肝纤维化后，20只给予吡喹酮病原治疗，另20只除病原治疗外给予抗胶原散治疗。结果表明．加抗胶原敬组治后，肝纤维化降级、肝脏原县减少、肝脏原纤维面积缩小、肝血流图舒张指数降低等均优于单纯病原治疗组，健康级服药结果显示抗胶原散无毒副作用。抗胶原散抗纤维化作用机制在于．一是活血化淤，改善肝微循环血流灌注．二是使用后血锌浓度明显升高，抑制了胶原生物合成的关键酶并提高胶原酶活性，促进胶原的降解．因此，我们的动物实验提示，肝纤维化是可逆的。
In this report, 40 out of 60 rabbits were infected with schistosomiasis and developed hepatic fibrosis. Twenty rabbits were given praziquantel for treatment of the disease, and the other 20 were treated with anti-collagen treatment in addition to pathogens. The results show. After treatment with anti-collagen, the liver fibrosis was degraded, the liver in the original county was reduced, the liver fibril area was reduced, and the diastolic index of hepatic blood flow was reduced. These were all superior to those of the simple pathogen treatment group. Health grade medication showed anti-collagen scattered and nontoxic side effect. Anti-collagen dispersion anti-fibrosis mechanism is. The first is blood circulation, improve liver microcirculation perfusion. The second is that serum zinc concentrations increase significantly after use, inhibit the key enzymes in collagen biosynthesis and increase collagenase activity and promote collagen degradation. Therefore, our animal experiments suggest that liver fibrosis is reversible.