论文部分内容阅读
帕金森病患者大脑黑质区多巴胺神经元的退化最明显。目前所知的用于帕金森病的治疗药物能够改善症状,却不能避免中脑多巴胺神经元的退化或死亡,进而引发相关的运动缺陷。胶质细胞源性神经营养因子(GDNF)是迄今所知的对多巴胺神经
The degeneration of dopaminergic neurons in the substantia nigra of Parkinson’s disease patients is most obvious. The currently known therapeutic drugs for Parkinson’s disease can ameliorate symptoms but can not prevent the degeneration or death of midbrain dopamine neurons, which in turn leads to related motor deficits. Glial cell-derived neurotrophic factor (GDNF) is hitherto known to dopamine neurons