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目的 对肝硬化门静脉高压症的术式及手术时机的选择提供依据。方法 对成年杂种犬进行脾静脉属支置管术 ,每周 3次经管内应用 0 .8ml/kg体重的 1 0 %CCl4 脂肪乳溶液 ,制备犬肝硬化模型。第 2、4、6、8、1 0周末采取小块肝组织 ,测定血清生化指标 ,进行吲哚氰绿排泄试验及口服糖耐量试验 ,并测取门静脉压力。结果 肝储备功能在用药 8～ 1 0周间下降显著 ,吲哚氰绿清除率由 0 .1 31± 0 .0 1 3降至 0 .0 52± 0 .0 0 9,吲哚氰绿 1 5min滞留率由 9.52± 1 .50升至 31 .30±8.50。口服糖耐量试验 (1 2 0min) (8.3± 0 .7)mmol/L升至 (1 4 .9± 2 .3)mmol/L。结论 肝硬化进展中 ,肝储备功能逐渐下降 ,肝功能、口服糖耐量试验及吲哚氰绿排泄试验 ,对肝硬化进展程度具有较高的评价价值
Objective To provide the basis for the selection of surgical procedures and timing of liver cirrhosis with portal hypertension. Methods Adult splenic dogs were treated with splenic vein support. Dogs with cirrhosis were prepared by intraperitoneal administration of 0. 8ml / kg body weight of 10% CCl4 fat emulsion three times a week. At the end of the 2nd, 4th, 6th, 8th and the 10th weeks, a small piece of liver tissue was taken for the determination of serum biochemical indexes, indocyanine green excretion test and oral glucose tolerance test, and the portal vein pressure was measured. Results The hepatic reserve decreased significantly from 8 to 10 weeks after treatment, the clearance rate of indocyanine green decreased from 0. 31 ± 0. 0 1 3 to 0. 52 ± 0. 0 0 9, indocyanine green 1 5min retention rate rose from 9.52 ± 1.50 to 31 .30 ± 8.50. The oral glucose tolerance test (120 min) was (8.3 ± 0.7) mmol / L to (14.9 ± 2.3 mmol / L). Conclusions In the progress of liver cirrhosis, the function of liver reserve gradually declines, liver function, oral glucose tolerance test and indocyanine green excretion test have a higher evaluation value on the progress of liver cirrhosis