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目的观察左旋卡尼丁联合促红细胞生成素治疗肾性贫血的疗效,并探讨其作用的可能机制。方法 30例维持性血液透析的终末期肾病患者,随机分为观察组和对照组,各15例。对照组给予促红细胞生成素,观察组在给予促红细胞生成素的同时,联合给予左旋卡尼丁,治疗时间12周,观察并比较治疗前后两组患者的外周血红蛋白浓度及红细胞压积。结果治疗后观察组较对照组外周血红蛋白浓度及红细胞压积显著升高(P<0.05);血透中高血压发生显著减少(P<0.05);血透中胃肠道不良反应发生显著减少(P<0.01)。结论左旋卡尼丁联合促红细胞生成素治疗肾性贫血有效。
Objective To observe the curative effect of L-carnitine combined with erythropoietin on renal anemia and to explore its possible mechanism. Methods Thirty patients with end-stage renal disease who underwent maintenance hemodialysis were randomly divided into observation group and control group, 15 cases each. The control group was given erythropoietin. The observation group was treated with erythropoietin simultaneously with levobisidine for 12 weeks. The peripheral hemoglobin concentration and hematocrit of the two groups were observed and compared before and after treatment. Results After treatment, peripheral blood hemoglobin and hematocrit were significantly increased (P <0.05) in the observation group and those in the control group were significantly lower than those in the control group (P <0.05). The adverse reactions of gastrointestinal tract in hemodialysis patients were significantly reduced (P <0.01). Conclusion L-carnitine combined with erythropoietin is effective in treating renal anemia.