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目的分析血管生成素-2(Ang-2)、热休克蛋白-90α(HSP90α)与老年非小细胞肺癌患者血清中表达情况,及其与TNM分期的相关性。方法选取2015年1月至2016年6月间新疆医科大学附属中医医院收治的40例老年非小细胞肺癌患者及40例体检健康者作为研究对象。检测受试者血清中Ang-2、HSP90α水平,并分析其与患者TNM分期相关性。结果观察组患者血清中Ang-2及HSP90α水平均明显高于对照组,差异有统计学意义(P<0.05);肿瘤TNMⅠ~Ⅱ期患者血清中Ang-2及HSP90α水平显著低于Ⅲ及Ⅳ期,差异有统计学意义(P<0.05);TNMⅢ期患者血清中Ang-2及HSP90α水平显著低于Ⅳ期,差异存统计学意义(P<0.05);TNM分期与患者血清中HSP90α水平呈正相关(r=0.425,P<0.05),TNM分期与患者血清中Ang水平呈正相关(r=0.525,P<0.05)。结论 Ang-2及HSP90α水平在老年非小细胞肺癌患者血清中呈显著高表达状态,且其表达水平与TNM分期呈正相关。
Objective To analyze the expression of angiopoietin-2 (Ang-2), heat shock protein-90α (HSP90α) and sera in elderly patients with non-small cell lung cancer (NSCLC) and their relationship with TNM staging. Methods From January 2015 to June 2016, 40 elderly patients with non-small cell lung cancer (NSCLC) and 40 healthy people who were admitted to TCM Hospital Affiliated to Xinjiang Medical University were selected as the study subjects. The levels of Ang-2 and HSP90α in the sera of the subjects were detected and their correlation with TNM staging was analyzed. Results The serum levels of Ang-2 and HSP90α in the observation group were significantly higher than those in the control group (P <0.05). The levels of Ang-2 and HSP90α in serum of patients with TNM Ⅰ ~ Ⅱ were significantly lower than those of Ⅲ and Ⅳ (P <0.05). The levels of serum Ang-2 and HSP90α in patients with TNM stage Ⅲ were significantly lower than those in stage Ⅳ, the differences were statistically significant (P0.05). The level of serum HSP90α in TNM stage patients was positive (R = 0.425, P <0.05). There was a positive correlation between TNM stage and serum Ang level in patients (r = 0.525, P <0.05). Conclusions The levels of Ang-2 and HSP90α in the serum of NSCLC patients were significantly higher than those of the non-small cell lung cancer patients, and the expression levels of Ang-2 and HSP90α were positively correlated with TNM stage.